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The mechanisms highlighted in this review do not occur in isolation, but instead are highly interconnected and often mutually reinforcing

YAP/TAZ activates inflammatory pathways such as STAT3 and NF-B, promoting the release of the pro-inflammatory factors like IL-6, IL-17, and TNF-, thereby forming a keratinocyte-immune cell positive feedback loop that exacerbates psoriatic pathology [48,49,50,51]

90%) , capsule type (softgel vs

In the future, precision medicine, guided by genetic variants, represents a promising avenue for tailoring hyperuricemia management to individualized needs