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Among the thiazolidinedione family members, troglitazone is considered the most potent inhibitor of ferroptosis due to its intrinsic antioxidant activity driven by the tryptophanol portion of its structure [80]

To replenish intracellular GSH, cells synthesize GSH in a two-step metabolic pathway centred on the rate-limiting enzyme glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a regulatory or modifier (GCLM) subunit, and the GSH synthetase (GS) 22

Drugs: FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs)

Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism