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doi: 10.1016/S0006-2952(02)01175-9 23

Using Tri-Luma Cream early in pregnancy may be more likely to produce birth defects than using it later in pregnancy

Shimaoka et al., 2000

In educational terms, the profile that comes up most often looks like this: Already active, targeting stubborn fat: someone with a reasonable diet and training routine looking at localized fat that has plateaued, not someone seeking a first-line solution