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Upon binding to DNA strand breaks, PARP transfers ADP-ribose units from the respiratory coenzyme nicotinamide adenine dinucleotide (NAD + ) to various nuclear proteins (e.g., DNA polymerase, histones, and an automodification domain of PARP itself), building up large ADP-ribose polymers that may reach up to 200 units (1150)

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Small 10 , 51705177 (2014) Ao, H., Feng, H., Li, K., Zhao, M., Qian, Z., Chen, J.: Coordinate bonding-induced emission of goldglutathione complex for sensitive detection of aluminum species