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Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy

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For instance, hypoxia-induced immunosuppression could potentially be reversed through co-administration of immune checkpoint inhibitors (313), while radiotherapy, which is less effective in hypoxic regions, may regain potency when combined with agents that reoxygenate tumors or sensitize hypoxic cells (314)