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Notably, the crystal structure revealed that the G-loop gate and inner helix gate are too constricted to conduct hydrated K + ions, suggesting the channel in the presence of PIP 2 is closed in this structure (Whorton and MacKinnon, 2011)

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PMID: 111 SongGHuPSongJLiuJRuanY

In addition, pesticides are known to stimulate the production of heat shock proteins and other molecular chaperones, which may explain the observed increase in protein levels at lower concentrations [83]