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Vitamins C and E help GSH do this better and regenerate

Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

In doing so, we provide the first assessment of these enzymes in sponges (phylum Porifera), including four marine and one freshwater species of three different classes