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Clinically, many late-onset MADD patients respond dramatically to high-dose riboflavin (100400 mg/day), confirming residual enzyme function amenable to cofactor restorationclassifying MADD as a prototype FAD-responsive metabolic myopathy (70)

Thus, the maintenance of a high redox potential is prerequisite for maintaining the reproductive systems in a healthy state

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Pregnancy and Breastfeeding: Pregnant and breastfeeding women need extra amounts of certain B vitamins, such as folate, to support fetal development and development during infancy