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In the current study, recurrence may be attributed to the sunny nature of our country even in winter which necessitate application of an efficient sun blocking agent frequently, this is an issue that is not guaranteed to be followed by all patients throughout treatment and follow-up period

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299 As shown in Figure 21, the synthesis of SAINT began with the reactions of dialkylation of 4-methylpyridine 103 and various alkyl bromides, giving alkylpyridine 104 , which was quaternized with methyl iodide to afford N -alkylpyridinium iodide 105

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