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Guideline group members consider SSRIs in individual cases as third line treatment with caution of possible side effects if all first- and second-line treatment options have, over an adequate amount of time, shown to be insufficient to control symptoms

Systematic review and network meta-analysis comparing antithrombotic agents for the prevention of stroke and major bleeding in patients with atrial fibrillation

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Most researchers report initial subtle improvements within 7 to 10 days, with significant changes in sleep quality emerging over 3 to 6 weeks