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ACS Chemical Biology, 14 (9), 20142023

Metformin enhances autophagic pathways, promoting the clearance of toxic protein aggregates [142]

9 This research notes the novel finding that as treatment progresses, if other issues related to serotonin and dopamine imbalance such as headache, anxiety, insomnia, etc, occur, 5-HTP may be secondarily titrated within 37.5 to 900 mg per day range