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Temperature matters significantly

The thread of ideas summarised in this review goes as follows: external effectors can cause fibrin to polymerise into an amyloid-type form (Figure 4 and Figure 5 and many references cited) that is more resistant than usual to fibrinolysis, and that the fibrinaloid microclots so formed (that can aggregate into macroclots) are the cause rather than the effect of atrial fibrillation