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doi: 10.1093/toxsci/kfl149 333 BuckleyJPKimHWongERebholzCM

PenningLCBerenguerMCzlonkowskaADoubleKLDusekPEspinosCet alA century of progress on Wilson disease and the enduring challenges of genetics, diagnosis, and treatment

The rate-limiting step in the glutathione synthesis pathway is catalyzed by glutamate cysteine ligase (GCL), which can be inhibited using Buthionine Sulfoximine (BSO) 52 (Fig

This means glutathione could help prevent skin from getting darker, for example, by curbing tanning or formation of new dark spots, rather than bleaching the skin in a dramatic fashion