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J Trace Elem Med Biol 62:126548

Targeting zonulin attenuates arthritis Next, and most importantly, we directly blocked zonulin by larazotide acetate (AT-1001), a first-in-class TJ regulator, currently used in phase III clinical trials for celiac disease 29

Biographies Ruth Nussinov pioneered the conformational selection and population shift (1999) as an alternative to the induced fit textbook model to explain the molecular mechanism of recognition and posited that population shift underlies allosteric regulation