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The RRF value was sharply reduced in cells of all strains following the application of severe stress: heat stress (48 C for 30 min) or oxidative stress (induced by a 0.75% hydrogen peroxide)

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EXOs have the same functions as MSCs, but they possess the added benefits of focused administration, minimal antigenicity and immunological rejection, and great repair potential (Wang et al., 2024d

In the mild forms, the active disease was self-limited to one year or more, and the patients returned spontaneously to a euthyroid state