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The balance of the different CRP isoforms, monomeric (mCRP) or native pentameric (nCRP) within the plaque determines the preponderance of a proinflammatory or anti-inflammatory effect, respectively (165)

This not only enhances their inflammatory potential but also affects antigen processing, glutathionylation of signaling proteins, and interactions with resident CNS cells such as microglia and astrocytes (Federici et al., 2024)

Immunotherapy with several cytokines protects the host and boosts bacterial clearance ( Table 2 )

Gabriella Clemente , Chris Rudnicky, Nadira Robinson-Burton, Jimmy Presto, David Lucente, Natalia Lattanzio, Puneet Mahal, Robert Gardner, Giorgio Ascoli, Theodore Dumas