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evidenced by reduced neurobehavioral deficits, decreased lesion size, and reduced chronic inflammation measured by GFAP (glial fibrillary acidic protein) staining four weeks after injury [76]

To investigate mechanisms underlying FTLD-GRN, single-cell transcriptomics in the thalamus and frontal cortex of Grn / mice and FTLD-GRN patients identified a conserved astrocytic pathology marked by upregulation of GJA1, AQP4 , and Apoe , and downregulation of the glutamate transporter SLC1A2

doi: 10.1016/j.jep.2023.116945 122 WolfPGDevendranSDodenHLLyLKMooreTTakeiHet al

Single-cell RNA-seq data processing and analysis Obtain the gene-cell matrix of dataset CNP0001102 and use the R package Seurat to perform Unsupervised clustering Cell clustering