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Mitochondrial Dysfunction in Autosomal Recessive Parkinsons Disease PARKIN Parkin is a cytoplasmic E3 ubiquitin ligase with an N-terminal ubiquitin-like domain (UBL) and a C-terminal ubiquitin ligase domain

doi: 10.1056/NEJMoa1706450 14 BardiaAHurvitzSATolaneySMLoiratDPunieKOliveiraMet al

Our analysis revealed that inflammatory gene expression changes consistently exceeded and preceded protein alterations, suggesting significant post-transcriptional regulation during toxic stress