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vitamin C is a single vitamin, ascorbic acid

synbiotics and psychobiotics seek to enhance effect sizes by pairing strains with substrate specificity and targeting mood/cognition-relevant circuits [242,243,244,245]

Additionally, clinical trials using nicotinamide for glaucoma neuroprotection have primarily tested a 3 g/day dose, which is 150 times the recommended daily intake (~20 mg/day), raising concerns about long-term safety in human use

An emerging alternative hypothesis is that partial agonism of MOR can lead to reduced side effects while preserving therapeutic effects (signaling efficacy hypothesis) 78,91