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The Transorb Technology, which utilizes a dual surfactant system and adjuvants, was first introduced in 1996 as Roundup ULTRA

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By inhibiting drug efflux pumps, suppressing pro-survival pathways (e.g., NF-B, PI3K/Akt/mTOR), and augmenting apoptotic signaling, curcumin can lower the effective dose of chemotherapy required to achieve a desired cytotoxic effect, potentially reducing dose-limiting toxicities