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Pyroptosis Pyroptosis is a distinct form of RCD characterized by the activation of inflammasomes and inflammation-associated caspases [136]

But even though its made in the liver, glutathione can be found in every cell of your body as well as some extracellular areas, like the lining of the lung [2]

A number of approaches targeting deficient GCase activity in GBA-PD have reached the stage of clinical phase 2/3 trials including orally active GCase chaperones to enhance enzymatic activity, substrate reduction therapies modelling current treatment of Gauchers disease and GBA gene therapy (Table 5)