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Low GPER mRNA levels are independently linked to lymph node metastasis, female sex, and BRAF mutations but are positively correlated with thyroid differentiation gene expression, suggesting that GPER is involved in PTC tumorigenesis

Reactive oxygen species (ROS) play a crucial role in cell signaling, however when the balance between ROS production and consumption is disrupted, it can lead to cell damage

Zheng C, Wei Y, Zhang P, Lin K, He D, Teng H, Manyam G, Zhang Z, Liu W, Lee HRL, Tang X, He W, Islam N, Jain A, Chiu Y, Cao S, Diao Y, Meyer-Gauen S, Hk M, Malovannaya A, Li W, Hu M, Wang W, Xu H, Kopetz S , Chen Y

76.2%, aHR for 90-day mortality 0.34 [95% CI 0.18, 0.65, p =0.001]), and better 90-day transplant-free survival (63.5% vs