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Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway, ACS Appl Mater Interfaces 13(34) (2021) 40354-40364.10.1021/acsami.1c11468

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Kidneyheart axis in crosstalk The kidney contributes to interorgan crosstalk through the secretion of hormones and proteins such as erythropoietin, renin, 220,221 and Klotho, 222,223 which have significant effects on the heart, muscle and adipose tissue

NAD+ Restoration (Anti-Aging): NNMT works by methylating nicotinamide, which removes it from the NAD+ salvage pathway. By blocking NNMT, 5-Amino-1MQ preserves nicotinamide, allowing the cell to recycle it back into NAD+ (Nicotinamide Adenine Dinucleotide)