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Moreover, cells receiving MCAP NPs treatment exhibited the highest intracellular ROS level, which was resulted from the multiple amplification of tumor oxidative stress including Mn 2+ -mediated Fenton reaction (Figures 1A,B), GSH depletion (Figures 1C, 5A), AS-boosted CDT (Figure 1D) and Ca 2+ -overloading-mediated mitochondrial dysregulation (Supplementary Figure S14)