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Additionally, LINC00958-containing exosomes induce M2 macrophage polarization, a tumor-supportive immune phenotype characterized by markers like CD206 and the expression of immunosuppressive genes such as IL-10 and Arg-1

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This finding raises the possibility of an important role of antioxidant function in modulating lifespan

Home Remedies to Try First: Sleep with your head slightly elevated to reduce overnight fluid accumulation Limit salt and alcohol intake, both of which contribute to swelling Apply cold compresses (chilled spoons or cold gel masks) to constrict blood vessels and reduce morning puffiness Use caffeine-based eye creams to temporarily tighten the under-eye skin Treat underlying allergies, which can cause chronic puffiness Effective Non-Surgical Treatments: Radiofrequency (RF) or Ultrasound Skin Tightening : Gently firms under-eye skin and reduces mild sagging or looseness Platelet-Rich Plasma (PRP) Therapy : Improves skin thickness and reduces inflammation naturally Hyaluronic Acid Fillers : Used to fill under-eye hollows that exaggerate puffiness, offering a smoother contour (must be carefully selected) Microneedling : Stimulates collagen production, improving texture and elasticity While non-surgical treatments are highly effective for mild to moderate puffiness , more severe under-eye bags caused by fat protrusion or skin laxity may require a surgical option like lower eyelid blepharoplasty for best results