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These antigens have been demonstrated to elicit immune responses in individuals with late-stage colorectal adenocarcinomas, as well as in in those with advanced adenomas, making them potential targets for vaccine prevention in individuals who are at high risk for cancer development, such as those with LS [132,133,134,135,136]

Cell 51 , 575586.e4 (2019)

Histopathology Tissues were trimmed and fixed in 10% neutral buffered formalin (NBF) except for the eyes with optic nerves, testes and epididymides, which were fixed in modified Davidsons solution for 2472 h