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Three important characteristics of the P-450 system have roles in drug-induced toxicity: 1

"Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers"

they are used as control medications, and not rescue medications) (Fanta, 2017)

For example, levonorgestrel are progestins with high androgenic activity and are more prone to cause acne and excess hair growth (hirsutism) than progestins with less androgenic activity