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doi: 10.1016/j.jep.2025.120240 30 XieYLinGGuoCTianJLongLZhaoLet al

10.1080/10495398.2024.2442351 108 JiaoJ.SastreD.FielM

MRP1, multidrug resistance protein 1

Upon delivery of B12 to the tissues by holo TC, receptor-mediated endocytosis occurs, after which holoTC enters acidic lysosomes where the transcobalamin protein is degraded, the B12 is released, and then converted to its cofactor forms (Allen et al., 2018)