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Validation of process optimization The optimal preparation conditions for rhCol III-LIPS were obtained using Design Expert 8.0.6 software with encapsulation efficiency as an indicator, which are as follows: a rhCol III-to-lipid ratio of 1:52.41, a membrane-material ratio of 4.31:1, an ultrasound time of 20.10 min, and an encapsulation efficiency of 91.89%

Nevertheless, across studies, lipid profile measures (total cholesterol, HDL-C, triglycerides), glucose, and insulin typically exhibit negligible or inconsistent variations, especially in short-duration interventions [102]

Additionally, antioxidants can reduce some toxic effects of mycotoxins (Liu et al., 2022a,b)

The oxidative phase is dedicated to the production of NADPH, which supports biosynthetic processes like fatty acid and steroid synthesis, and helps maintain cellular redox balance by protecting against oxidative stress