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Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102

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When researchers reference all four compounds together, its typically because each represents a different node in metabolic and growth-hormone research: AOD-9604 for its fragment-based lipid pathway, MOTS-c for mitochondrial signaling, Tesamorelin for GHRH receptor stimulation, and Ipamorelin for ghrelin receptor-mediated growth hormone release