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Research applications include NNMT pharmacology, methyltransferase signaling studies, enzymatic regulation investigations, and mechanistic evaluation of nicotinamide methylation pathways

In post-viral syndromes, chronic neuroinflammation often causes excess glutamate to accumulate in the synaptic cleft, where it becomes highly neurotoxic and overstimulates neurons to the point of cell death

Andersen N, Corradi J, Sine SM, Bouzat C (2013) Stoichiometry for activation of neuronal 7 nicotinic receptors

Chronic stress, maternal deprivation, and olfactory bulbectomy are among the models that present higher degrees of face validity (i.e., animal behavior correlates with MDD symptomatology), predictive validity (i.e., good chances of replicating the positive or negative results in human patients), and construct validity (i.e., consistent underlying pathology biomarkers, triggering factors, time course, and response to antidepressants)