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However, though resveratrol is known to prevent oxidative stress in human lens epithelial cells, its effects on lens stiffness and the progression of the near vision impairment remain unknown

Consistent with a direct anti-inflammatory effect in multiple cell types, FGF21 inhibits macrophage expression of the pro-inflammatory cytokines TNF, IL-6, IL-1, and IFN- by inducing NRF2 nuclear translocation, thereby blocking NF-B activation (177)