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Collectively, these interconnected mechanisms highlight that drought tolerance emerges from dynamic coordination among redox signaling, hormonal regulation, and metabolic plasticity rather than from single-pathway responses

Although endothelial activation and redox signaling compose a normal host defense, when this activation is sustained, chronic production of ROS may exceed the capacity of cellular enzymatic and nonenzymatic antioxidant defenses [49], contributing to triggering vascular diseases such as atherosclerosis or peripheral artery disease [102, 103]