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Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)

It is necessary for the growth and replication of all body cells and the nervous system's functioning, and deficiency causes pernicious anemia and other forms of megaloblastic anemia and neurologic lesions