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10.1016/j.cmet.2019.08.021 15 ChenY.-m.LiuY.ZhouR.-f.ChenX.-l.WangC.TanX.-y.et al (2016)

(1996) Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans

*This statement has not been evaluated by the Food and Drug Administration

Consequently, MMAemia-related neuropathology manifests through dual mechanisms: direct metabolite toxicity (primary and secondary metabolites) and aberrant PTMs (notably methylmalonylation, propionylation, and acetylation)