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The complex nature of HLA class II alleles in MS, including allelic heterogeneity and gene-environment interactions, suggests that cobalamin deficiency may be influenced by multiple genetic and environmental factors [156]

Various strategies and methods must be employed to combat the abiotic stress-inducing factors because these factors can generate internal cellular stress, including oxidative stress caused by over-produced reactive oxygen species (ROS) in fish and other organisms (Paital, 2013, 2014)

NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment