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Another systematic review and comprehensive analysis indicated that antidepressants vary in their ability to enter amniotic fluid, cord blood, and breast milk, with citalopram having the highest permeability (mean permeability of active molecules: 2.03, range: 0.356.97) and fluoxetine having the lowest permeability (mean permeability of active molecules: 0.11, range: 0.020.20) (Figure 2)

Accumulation of lipids is considered to be the first hit that further increases the susceptibility of the liver to various factors that constitute the second hit, leading to inflammation, hepatic injury, and fibrosis[8]

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