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Regarding glutathione synthesis, its first step, the formation of -EC takes place in the chloroplasts and its transcriptional regulation by light intensity (higher expression under conditions of low light intensity than under normal light intensity) and far-red light (lower expression under white light with decreased red/far-red ratio) was shown in wheat (Gasperl et al

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Although early investigations have shown that antioxidant supplements had modulating effects on oxidative stress and AMS symptoms at high altitudes [94, 95], more recent studies indicate no effect [96,97,98] or mixed results [99]