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Ursodeoxycholic acid (UDCA) and its taurine conjugate, tauroursodeoxycholic acid (TUDCA), are well-established for their cytoprotective and anti-inflammatory properties (133), while potentially mediating anti-inflammatory effects in colonic inflammation through FXR activation and M2 macrophage polarization (100), direct cytoprotection) underscore their therapeutic versatility in modulating immune responses

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In addition, phenotypes consistent with IPD can be induced by several endogenous and exogenous inhibitors of mitochondrial function, including rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP), paraquat, nitric oxide, and the dopamine metabolite aminochrome (Bellou et al., 2017)

81 Further, Liu et al showed that early intervention using quercetin liposomes in RILI model mice reduced MDA contents in lung tissue, increased SOD and GSH-PX activities, and reduced the proportion of inflammatory cells and HP content in the BALF.Meanwhile, histological examination using HE staining showed suppression of the inflammatory response and reduced fibrosis scores in the lungs