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10.4254/wjh.v12.i5.184 43 KonosicS.PetricevicM.IvancanV.KonosicL.GoluzaE.KrtalicB.et al (2019)

sinensis may rely on an alternative reductive metabolic pathway for cordycepin biosynthesis (Xiang et al., 2014) (lower right corner in Figure 1): AMP is converted to ADP by adenylate kinase (ADEK), then reduced to 3-dADP by ribonucleotide reductase (NRDJ), followed by dephosphorylation to 3-dAMP by ADEK, and finally converted to cordycepin through a dephosphorylation reaction catalyzed by 5-nucleotidase (NT5E)