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J King Saud University-Science 32:25342539 Wang Z, Sun R, Wang G, Chen Z, Li Y, Zhao Y, Liu D, Zhao H, Zhang F, Yao J (2020c) SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury

Overall, the literature suggests that curcumin exerts its beneficial effects through modulation of various signaling pathways, including NF-B, NLRP3, AKAP150/PKA/PP2B, miR-146a-5p/ERK, BDNF/Trkin, ROS-ERK1/2, GABAA receptor, gut-brain axis and Keap1-Nrf2-ARE, in different disease models and conditions