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261 On the other hand, SIRT4 suppresses tumor growth by inhibiting glutamine metabolism, 262,263 and upon downregulation, it inhibits apoptosis and desensitizes cancer cells to chemotherapy

Disorderd taste sensation, such as altered taste or metallic taste (termed dysgeusia ), is associated with poor nutrition and can reduce quality of life (Snchez-Lara 2010

Mendoza-Soto AB, Naya L, Leija A, Hernndez G

revealed that the LN microenvironment can reprogram cancer cells, leading to an elevation in interferon-induced gene signatures, which subsequently caused the upregulation of MHC class I and PD-L1 gene expression in cancer cells ( Figure 2