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Description

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Lipid peroxidation disrupts cell membranes, protein oxidation leads to loss of function and structural integrity, and DNA damage can cause mutations and genomic instability [9]

First, the bioavailability and hepatic delivery of many dietary antioxidants (e.g., polyphenols, vitamins C and E) are often low and highly variable between individuals

Lipid rafts: Buffers of cell membrane physical properties