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Description

We assessed the possible pathogenicity of these novel variants based on four bioinformatic tools (SIFT, PolyPhen-2, PROVEAN, and MutationTaster) integrated in VarSome (Kopanos et al., 2019)

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18 Depakote is stronger for acute mania and mixed states, while lamotrigine is better known for preventing bipolar depression and has limited utility in acute mania