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As discussed above, ()-Phen is a highly potent inhibitor of AChE (IC 50 = 22-36 nM) in plasma and brain, as are its N1-nor and N1,N8-bisnor metabolites [74]

2021), both known for their antioxidant properties, have been demonstrated to attenuate sevoflurane-induced oxidative stress by neutralizing ROS and suppressing associated inflammatory responses

It is also important to point out that each study has its limitations, whether it is a small sample size which reduces the statistical power of the study (32, 36, 4851), heterogeneity of COPD patients enrolled in the studies such as grouping of subjects with different GOLD stages into one group, as in a study by Pierrou et al

Garcia-Tsao G, Bosch J, Kayali Z, Harrison SA, Abdelmalek MF, Lawitz E, Muellhaupt B (2020) Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension