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Altered autophagosome processing triggers abnormal iron accumulation, activating the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome via the cyclic GMP-AMP synthase-stimulator of interferon genes (CGAS-STING1) pathway (an autophagy-related pathway), leading to oxidative stress and ferroptosis

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Unless the oxidizing environment of the periplasm induces the formation of GSSG our data suggests that Gsi is capable of transporting reduced glutathione, albeit significantly less efficient than GSSG

The indication for PPI use was documented in 6,326 encounters (58.2%) with GERD (n=5,127, 47.2%), gastric or duodenal ulcer (n-1,453, 13.4%), and multiple indications (n=1,627, 15.0%) as the most common indications