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Stiffening occurs with the loss of elastin/collagen, which reduces oxygen flow in blood vessels

Identification of the same variant in family 6, who present with a similar and consistent phenotype, and reanalysis using the ACMG guidelines has deemed this variant likely pathogenic (Table 2)

The third clinical trial launched by the SP754 Study Group which solely recruited American patients also confirmed the long-term efficacy and tolerability of adjunctive LCM in the treatment of epilepsy [167]