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In patients with cystic fibrosis (CF), who experience elevated elastase levels in the airways, increased iron and ferritin concentration have been observed in sputum and bronchoalveolar lavage samples ( In individuals with A1AT deficiency, with Z and S polymorphisms, there is a significant accumulation of iron in the liver ( Studies have also reported significant differences in plasma ferritin concentrations between individuals with different A1AT genotypes

This inhibitory action, which is in accord with opposing effects of various metalloporphyrins on HMOX,15 might contribute to anti-carcinogenic effects observed in our study and also, at least in part, account for chemopreventive effects of chlorophyll-rich nutrients

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