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Inflammasome activation and IL-1 and IL-18 processing during infection

In the obese state, WAT undergoes selective rewiring of protein-protein interaction networks, resulting in interactions that are markedly enhanced or uniquely detectable in obese WAT [64]

Current clinical strategies for the management of PDN include glycolic control and treatment with drugs such as tricyclic compounds, serotonin noradrenalin reuptake inhibitors, -lipoic acid, anticonvulsants, opiates, membrane stabilizers and topical capsaicin

This emphasizes the potential of SEPT9 and HAND1 methylation as promising biomarkers for the diagnosis of CRC, leading to early detection and improved patient outcomes (Shavali et al., 2024)