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AMD: age-related macular degeneration AP-1: activator protein-1 BCL-2: B-cell lymphoma 2 COX: cyclooxygenase CYP2E1: cytochrome P450 2E1 DC: dendritic cell DHA: docosahexaenoic acid GITs: gastrointestinal tracts GPx: glutathione peroxidase GSH: glutathione GST: glutathione S -transferase HDL: high-density lipoprotein HO-1: heme oxygenase-1 IBD: inflammatory bowel disease IL-10: interleukin-10 iNOS: inducible nitric oxide synthase I-B: inhibitor of kappa B JAK: Janus kinase Keap1: Kelch-like ECH-associated protein 1 LDL: low-density lipoprotein LPS: lipopolysaccharide MDA: malondialdehyde MI: myocardial infarction MIAT: myocardial infarction associated transcript miR: micro-RNA NADPH: nicotinamide adenine dinucleotide phosphate NF-B: nuclear factor kappa B NOX: nicotinamide adenine dinucleotide phosphate oxidase Nrf2: nuclear factor erythroid 2-related factor 2 NSAIDs: non-steroidal anti-inflammatory drugs PC-3: prostate cancer cell line PI3K: phosphatidylinositol 3-kinase PPAR: peroxisome proliferator-activated receptor alpha RANKL: receptor activator of nuclear factor kappa B ligand ROS: reactive oxygen species RXR: retinoid X receptor alpha SOD: superoxide dismutase STAT: signal transducer and activator of transcription TG: triglycerides TNF-: tumor necrosis factor- The authors thank all colleagues who contributed to the preparation of this manuscript, providing support through its development, assisting in the formatting, and making final corrections

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